Will Graphene Nanoparticles be used for Targeted Delivery of siRNA to the Brain?


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The authors present a method for developing “siRNA” therapies using interfering RNA to treat brain diseases. Porous silicon nanoparticles coated with graphene oxide have been shown to carry a viral RNA cargo that can enter the target area and bypass immune system activation.

Treatment of Brain Diseases

This allows the siRNA cargo to accumulate in the affected or injured area of the brain targeted for genetic modification of the disease, causing gene interference and silencing.

In fact, it says, “Efforts to overcome these obstacles have resulted in a number of siRNA delivery strategies. A number of approaches have been pursued to increase stability and circumvent immune activation through the use of viral or non-viral nanocarrier systems.

Viral vectors that transport siRNAs in the form of the viral genome have been shown to effectively accomplish gene silencing, but scaling challenges, low delivery capacity, and safety concerns such as mutagenesis or immunogenicity have limited clinical implementation of these constructs to date. ”

The article refers to the method of administration of the nanoparticle solution, “Intravenous administration of nanoparticles to brain-injured mice results in significant accumulation specifically at the site of injury.

Reviews

The article shows that graphene oxide is used as a carrier or vector for viral RNA loads. This suggests that it is possible to deliver a virus through graphene oxide nanoparticles and that they reach the brain.

This is very revealing because it implies that a way has been found to penetrate the brain’s impregnable enclosure to alter its genetics, to affect its functioning with gene therapies or gene silencing, using a process very similar to that of vaccines against Corona virus.

Hypothesis

It is hypothesized that vaccines against coroavirus, which show strong evidence for the presence of graphene oxide (Campra, P. 2021), serve to transport messenger RNA mRNA, but also other types of RNA, such as siRNA for gene silencing or interference. All this leads to the possibility of them transporting viral cargoes and even human gene editing with CRISPR techniques.

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Bibliography

Campra, P. (2021). [Report]. Detection of graphene oxide in aqueous suspension (Comirnaty ™ RD1): observational study in optical and electron microscopy. University of Almería. https://docdro.id/rNgtxyh

 

Reference

Joo, J., Kwon, EJ, Kang, J., Skalak, M., Anglin, EJ, Mann, AP, … and Sailor, MJ (2016). Porous silicon graphene oxide core-shell nanoparticle for targeted delivery of siRNA to the injured brain. Nanoscale Horizons, 1 (5), pp. 407-414.

https://pubs.rsc.org/en/content/articlelanding/2016/NH/C6NH00082G