“Let’s start with a thought experiment: If a design flaw exists and no one measures it, can it really hurt or kill people?” writes a Twitter user named Ehden.
COVID Recordings Use Codon Optimization
He goes on to discuss an overlooked aspect of COVID mRNA recordings called “codon optimization,” which virtually guarantees unexpected results.
Trying to tell the body to make proteins is difficult for many reasons. One of them is the fact that trying to run the protein information across the ribosomes that process that code and make the protein can be very slow or get stuck during the process.
Fortunately, scientists have found a way to overcome this problem by performing a code substitution: Instead of using the original genetic code to create the protein, they changed the letters of the code to optimize the code. This is called codon optimization.
A codon is made up of three nucleotides, and nucleotides are the building blocks of DNA. In an August 2021 article in Nature Reviews Drug Discovery, codon optimization is described as follows:
The open reading frame of the mRNA vaccine is the most important component because it contains the coding sequence that is translated into protein.
Although the open reading frame is not as malleable as the noncoding regions, it can be optimized to increase translation without altering the protein sequence by replacing infrequently used codons with more abundant codons that code for the same amino acid residue.
For example, biopharmaceutical company CureVac AG discovered that human mRNA codons rarely have A or U in the third position and patented a strategy that replaces A or U in the third position with G or C in the open reading frame. CureVac used this optimization strategy for its SARS-CoV-2 candidate CVnCoV …
Although the replacement of rare codons is an attractive optimization strategy, it must be used judiciously. This is because for some proteins, the slower translation rate of the rare codons is necessary for proper protein folding.
To maximize translation, the mRNA sequence usually contains modified nucleosides such as pseudouridine, N1-methylpseudouridine, or other nucleoside analogs. Because all native mRNAs contain modified nucleosides, the immune system has evolved to recognize unmodified single-stranded RNA, which is a hallmark of viral infection.
Specifically, unmodified mRNA is recognized by pattern recognition receptors such as Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the receptor for retinoic acid-inducible gene I (RIGI). TLR7 and TLR8 receptors bind to guanosine- or uridine-rich regions in mRNA and trigger the production of type I interferons, such as IFNα, which can block mRNA translation.
The use of modified nucleosides, particularly modified uridine, prevents recognition by pattern recognition receptors and allows sufficient translation to produce prophylactic amounts of protein.
Both the Moderna and Pfizer BioNTech SARS-CoV-2 vaccines … contain nucleoside-modified mRNAs. Another strategy to avoid recognition by pattern recognition receptors, pioneered by CureVac, uses sequence engineering and codon optimization to reduce uridines by increasing the GC content of vaccine mRNA.
Much of this information has already been discussed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D.. You cannot see the article, but the video is embedded above. This study was published long after our interview and simply confirms what Seneff and Mikovits found in their research.
According to Ehden, 60.9% of codons in COVID recordings were optimized, which corresponds to 22.5% of nucleotides, but he does not specify which recording he is talking about or exactly where the data came from.
However, it is clear that all mRNA COVID uptakes use codon optimization to one degree or another. A July 2021 article in Vaccines specifically evaluates and comments on the Pfizer/BioNTech and Moderna mRNA vaccines and states:
The design of the Pfizer/BioNTech and Moderna mRNA vaccines involves many different types of optimizations … The mRNA components of the vaccine must have a 5′-UTR to efficiently load ribosomes onto the mRNA for translation initiation, optimized codon usage for efficient translation elongation, and an optimal stop codon for efficient translation termination.
Both the 5′-UTR and the downstream 3′-UTR should be optimized for mRNA stability. Replacement of uridine with N1-methylpseudourinine (Ψ) complicates some of these optimization processes because Ψ wobbles more versatilely than does U. Different optimizations may conflict with each other, and tradeoffs must be made.
I highlight the similarities and differences between Pfizer/BioNTech and Moderna mRNA vaccines and discuss the advantages and disadvantages of each process to facilitate future vaccine improvements. In particular, I point out some optimizations in the design of the two mRNA vaccines that were not done properly.
What can go Wrong?
An important insight from the Nature Reviews Drug Discovery article cited above is that replacing rare codons “must be used judiciously” because rarer codons may have a slower translation rate and a slower rate is actually necessary to prevent protein misfolding.
The spike protein is the toxic part of the virus that is responsible for the virus’ clearest effects, such as blood clotting disorders, neurological problems and heart damage. To expect the COVID shot to have no such effects would be quite naive.
A’s (adenine) and U’s (uracil) in the third position are rare, and COVID injections replace these A’s and U’s with G’s (guanine) or C’s (cytosine). According to Seneff, this replacement results in a 1,000-fold increase in spike protein compared to infection with the actual virus.
What can go wrong? Well, pretty much anything. Again, the shot induces spike proteins at levels not found in nature (even if SARS-CoV-2 is a “souped-up” artificial concoction), and the spike protein is the toxic part of the virus responsible for the major effects of the virus, such as blood clotting disorders, neurological problems, and heart damage.
So it would be quite naïve to expect the COVID shot to have no such effects. The codon switches could also lead to protein misfolding, which is also bad news. As Seneff explained in our earlier interview:
The spike proteins that produce these mRNA vaccines cannot penetrate the membrane, which I think leads to them becoming a problematic prion protein. Then, when inflammation occurs, alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release] is upregulated.
So alpha-synuclein gets pulled into misfolded spike proteins, which become a mess in the dendritic cells in the germinal centers of the spleen. And they package all this crud into exosomes and release them. These then travel along the vagus nerve to the brain stem and cause things like Parkinson’s disease.
So I think this is a complete set-up for Parkinson’s … It’s going to bring forward the time when someone who has a propensity for Parkinson’s is going to get it.
And it’s likely to cause people to get Parkinson’s who wouldn’t have gotten it in the first place – especially if they get vaccinated every year. With each booster shot, the date when one will get Parkinson’s gets closer and closer.
Immune Deficiency and Viral Flare-Ups
Other major dangers include immune deficiencies and flare-ups of latent viral infections, which Mikovits has already warned about. In our earlier interview, she said:
We use poly(I:C) [an agonist of Toll-like receptor 3] to signal the cell to turn on the type I interferon pathway, and because [the spike protein your body produces in response to the COVID shot] is an unnatural synthetic envelope, you don’t see poly(I:C), and you don’t [activate] the type I interferon pathway.
You have bypassed the plasmacytoid dendritic cell, which, in conjunction with IL-10, decides which subclasses of antibodies to produce by talking to the regulatory B cells. So they have bypassed the communication between the innate and adaptive immune responses. Now the endocannabinoid receptor signaling is missing …
A lot of the work that Dr. [Francis] Ruscetti and I have done over the last 30 years has been to show that you don’t need an infectious, transmissible virus – just bits and pieces of those viruses are worse because they also trigger danger signals. They act like danger signals and pathogen-associated molecular patterns.
That means they synergistically trigger this inflammatory cytokine signature that makes the innate immune response go out of control. It just can’t keep up with myelopoiesis [the production of cells in your bone marrow]. Therefore, there is a shift away from mesenchymal stem cells to TGF-beta-regulated hematopoietic stem cells.
This means that bleeding disorders can occur on both sides. You can’t make enough fire engines to send them into the fire. The innate immune response can’t get there, and then you have a total immune system wreck.
There are now reports of herpes and shingles infections following COVID-19 injection, and that’s exactly what can be expected if the type I interferon pathway is turned off. That’s not the end of the potential problems, however, because these coinfections could also accelerate other diseases.
For example, herpesviruses have been implicated as triggers of AIDS and myalgic encephalomyelitis (chronic fatigue syndrome or ME-CFS). According to Mikovits, these diseases only occur when viruses from different families join forces and retroviruses switch off the type 1 interferon signaling pathway. In the long run, the COVID mass injection campaign could lay the groundwork for a fast-approaching avalanche of a wide range of debilitating chronic diseases.
Are COVID Vaccinations Appropriately Optimized?
As noted in the previously cited article on vaccines, codon optimization may be problematic for Pfizer and Moderna vaccines:
Because mammalian host cells target unmodified exogenous RNA, all U nucleotides have been replaced by N1-methylpseudouridine (Ψ). However, Ψ wiggles more strongly than U during base pairing and can pair not only with A and G, but to a lesser extent with C and U as well.
This is likely to increase the misreading of a codon by a near-cognate tRNA. When the nucleotide U in stop codons was replaced by Ψ, the rate of misreading of a stop codon by a near cognate tRNA increased.
Such read-through events would not only reduce the number of immunogenic proteins but also generate a longer protein with unknown fate and potentially deleterious effects …
The developers of both vaccines considered CGG to be the optimal codon in the CGN codon family and recoded almost all CGN codons into CGG … [M]ore evidence suggests that CGC is a better codon than CGG. The developers of the mRNA vaccines (especially mRNA-1273) have chosen an incorrect codon as the optimal codon.
The paper also notes the importance of ensuring that a vaccine’s mRNA is translated accurately, not just effectively, because if the wrong amino acids are incorporated, it can confuse the immune system and prevent it from identifying the correct targets.
Accuracy is also important when stopping translation, and here it comes down to choosing the right stop codons. Stop codons (UAA, UAG, or UGA) located at the end of an mRNA coding sequence signal the termination of protein synthesis.
According to the author, both Pfizer and Moderna have chosen less than optimal stop codons. “UGA is a poor choice for a stop codon, and UGAU in the Pfizer/BioNTech and Moderna mRNA vaccines may be even worse,” she says.
What Health Problems Should We Expect?
While there are myriad diseases that could increase as a result of this vaccination campaign, some general predictions can be made. We’ve already seen a massive increase in blood clotting disorders, heart attacks and strokes, and heart inflammation.
In the long term, Seneff anticipates a significant increase in cancer, accelerated Parkinson’s-like diseases, Huntington’s disease, and all kinds of autoimmune and neurodegenerative disorders.
Mikovits also suspects that many will develop chronic and debilitating diseases and die prematurely. She sees the highest risk in those who are asymptomatically infected with XMRVs and gammaretroviruses from contaminated conventional vaccines. The COVID vaccine will effectively hasten their death by paralyzing their immune function. “The children who are highly vaccinated are ticking time bombs,” Mikovits said in my May 2021 interview.
What are the Options?
Although all of this is highly problematic, there is hope. In my opinion, the best thing you can do is to strengthen your innate immune system. To do this, you need to be flexible with your metabolism and optimize your diet. You should also make sure to optimize your vitamin D levels to between 60 ng/ml and 80 ng/ml (100 nmol/L to 150 nmol/L).
I also recommend eating a time-restricted diet, where you eat all of your meals for the day within a six- to eight-hour window. A timed diet also stimulates autophagy, which can aid in the digestion and breakdown of spike protein. Avoid all vegetable oils and processed foods. Focus on certified organic foods to minimize glyphosate exposure.
Sauna therapy can also be helpful. It stimulates heat shock proteins, which can help refold misfolded proteins. They also mark damaged proteins and remove them selectively.
Watch the Video Here: